Oligogenic analysis across broad phenotypes of 46,XY differences in sex development associated with NR5A1/SF-1 variants: findings from the international SF1next studyResearch in context

Summary: Background: Oligogenic inheritance has been suggested as a possible mechanism to explain the broad phenotype observed in individuals with differences of sex development (DSD) harbouring NR5A1/SF-1 variants.Methods: We investigated genetic patterns of possible oligogenicity in a cohort of 30 individuals with NR5A1/SF-1 variants and 46,XY DS

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Protocol for applying the Learning Environment Diversity, Equity, and Inclusion tool to asynchronous health professions courses

Health professions education must move beyond knowledge and skills-based domains to address student agency in diversity, equity, and inclusion.When DEI is addressed in health occupation courses, students have increased ability to maintain cultural competency, contribute to health disparity reduction, and foster a diverse health professions workforc

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Genome sequences of human cytomegalovirus strain TB40/E variants propagated in fibroblasts and epithelial cells

Abstract The advent of whole genome sequencing has revealed that common laboratory strains of human cytomegalovirus (HCMV) have major genetic deficiencies resulting from serial passage in fibroblasts.In particular, tropism for epithelial and endothelial cells is lost due to mutations disrupting genes UL128, UL130, or UL131A, which encode subunits o

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